Resolving Bax-Drp1 interactions during apoptosis published in EMBOJ!

January 13, 2022 – Ana Garcia-Saez and team published a beautiful story showing physical interactions between Bax and Drp1 on mitochondrial membranes during apoptosis. This interaction plays a critical role in mediating the release of cytochrome C into the cytoplasm to potentiate the cell death cascade. Jason’s development of the dimerization dependent fluorescent biosensors (ddFBs) to resolve endoplasmic reticulum and processing (P)-body contact sites overlapped with Raquel Salvador-Gallego’s (Ana’s PhD student) time in the Voeltz Lab. Our collaboration fostered the use of ddFBs in the spatiotemporal resolution of Bax and Drp1 interactions on mitochondrial membranes upon the initiation of cell death. Check it out at EMBOJ!

Figure 1E from Jenner et al. EMBOJ (2022) of HeLa cells expressing RA-Bax, GB-Drp1, MitoBFP. The interactions between Bax and Drp1 are pseudocolored in green. The general mitochondrial marker is pseudocolored in magenta. Experiments above were conducted by Raquel Salvador-Gallego.

Joshua has been awarded a NIEHS T32 Fellowship!!

January 1, 2022 – Happy New Year and great news! Joshua Marcus, Ph.D. gave an excellent presentation of his preliminary studies in the J. Lee Lab and was selected to a one year appointment with The Precision Environmental Health Sciences (TPEHS) T32 Fellowship Program with the National Institute of Environmental Health Sciences (NIEHS). Joshua will be studying the effects of environmental stress on cytoplasmic organization with a focus on interactions between the endoplasmic reticulum and stress granules.

Our TurboID Mass Spec samples arrived safely in San Diego!!

December 15, 2021 – Jason combined work and play to drive the lab’s 85! samples to our collaborator in San Diego. There, he met is partner and daughter to spend several days at the beach to celebrate his daughter’s 3rd birthday. Pictured is moonset (City of Rocks State Park, New Mexico) that he captured on the solo drive back to Houston.

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1st Holiday Party

December 17, 2021 – We celebrated a fun and productive 2021 with our first lab holiday party! Steaks, salmon, roasted veggies, mushroom risotto and carrot cake filled our bellies. It was great to hear everyone’s stories and to see that the lab chemistry experiment has successful beginnings. Here’s to more growth in 2022!

Welcome to the lab, Jue!!

February 23, 2021 – Our lab is pleased to welcome Jue “Jeremy” Wang! Currently, Jue is a Rice undergraduate student studying biology and asian studies. Jue has cell biology experience from James McNew’s Lab at Rice University where he was conducting experiments on atlastins, a family of proteins that shape the endoplasmic reticulum network. We are excited to have Jue join us for the Spring semester!

Welcome aboard Zach!

September 24, 2020 – We are pleased to have a new member joining the lab in October. Zach graduated earlier this year from Claremont Mckenna College where he was a member of the football team and of Zhaohua Irene Tang’s lab. We are excited that Zach will continue his scientific development in our lab!

Jason is a CPRIT Scholar!

May 20, 2020 – The Cancer Prevention and Research Institute of Texas awarded Jason’s research program with a First-Time, Tenure Track Faculty Award. The generous CPRIT grant will fund the lab’s quest to understand how inter-organelle contact sites are utilized in cancer cells.

https://www.cprit.state.tx.us/news-events/articles/cancer-prevention-research-institute-of-texas-awards-56-million-in-new-grants/